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Article

cGMP inhibition of Na+/H+ antiporter 3 (NHE3) requires PDZ domain adapter NHERF2, a broad specificity protein kinase G-anchoring protein.

The Journal of biological chemistry - 29 Apr 2005

Cha Boyoung, Kim Jae Ho, Hut Hans, Hogema Boris M, Nadarja Janani, Zizak Mirza, Cavet Megan, Lee-Kwon Whaseon, Lohmann Suzanne M, Smolenski Albert, Tse Chung Ming, Yun Chris, de Jonge Hugo R, Donowitz Mark

Abstract excerpt

Electroneutral NaCl absorption mediated by Na+/H+ exchanger 3 (NHE3) is important in intestinal and renal functions related to water/Na+ homeostasis. cGMP inhibits NHE3 in intact epithelia. However, unexpectedly it failed to inhibit NHE3 stably transfected in PS120 cells, even upon co-expression of cGMP-dependent protein kinase type II (cGKII). Additional co-expression of NHERF2, the tandem PDZ domain adapter...

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Source

Identifiers

PMID: 15722341
DOI: 10.1074/jbc.M500505200

Genes

NHERF2
NHERF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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cGMP inhibition of Na+/H+ antiporter 3 (NHE3) requires PDZ domain adapter NHERF2, a broad specificity protein kinase G-anchoring protein.PMID 15722341Read ↗

Both NHERF3 and NHERF2 are necessary for multiple aspects of acute regulation of NHE3 by elevated Ca2+, cGMP, and lysophosphatidic acid.Semantic proximity Read ↗

Phospholipase C-gamma binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity.Semantic proximity Read ↗

PDZ domain-dependent regulation of NHE3 protein by both internal Class II and C-terminal Class I PDZ-binding motifs.Semantic proximity Read ↗

Catalytic region mimetics in Na+/H+ exchanger regulatory factor 4 suppress Guanylate Cyclase 2C activity to regulate enterotoxin triggered diarrheaSemantic proximity Read ↗

Noncanonical Sequences Involving NHERF1 Interaction with NPT2A Govern Hormone-Regulated Phosphate Transport: Binding Outside the Box.Semantic proximity Read ↗

ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.Semantic proximity Read ↗

NHE3 inhibits PKA-dependent functional expression of CFTR by NHERF2 PDZ interactions.Semantic proximity Read ↗

Separate C-terminal domains of the epithelial specific brush border Na+/H+ exchanger isoform NHE3 are involved in stimulation and inhibition by protein kinases/growth factors.Semantic proximity Read ↗

Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers.Semantic proximity Read ↗

Intestinal anion exchanger down-regulated in adenoma (DRA) is inhibited by intracellular calcium.Semantic proximity Read ↗

The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange.Semantic proximity Read ↗

Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2.Semantic proximity Read ↗

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