Article
Interferon-gamma inhibits enterocyte migration by reversibly displacing connexin43 from lipid rafts.
American journal of physiology. Gastrointestinal and liver physiology - 1 Sept 2008
Leaphart Cynthia L, Dai Shipan, Gribar Steven C, Richardson Ward, Ozolek John, Shi Xia-hua, Bruns Jennifer R, Branca Maria, Li Jun, Weisz Ora A, Sodhi Chhinder, Hackam David J
Abstract excerpt
Necrotizing enterocolitis (NEC) is associated with the release of interferon-gamma (IFN) by enterocytes and delayed intestinal restitution. Our laboratory has recently demonstrated that IFN inhibits enterocyte migration by impairing enterocyte gap junctions, intercellular channels that are composed of connexin43 (Cx43) monomers and that are required for enterocyte migration to occur. The mechanisms by which IFN...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.