Article
HLA-associated immune pressure on Gag protein in CRF01_AE-infected individuals and its association with plasma viral load.
PloS one - 17 Jun 2010
Gesprasert Goragoch, Wichukchinda Nuanjun, Mori Masahiko, Shiino Teiichiro, Auwanit Wattana, Sriwanthana Busarawan, Pathipvanich Panita, Sawanpanyalert Pathom, Miura Toshiyuki, Auewarakul Prasert, Thitithanyanont Arunee, Ariyoshi Koya
Abstract excerpt
BACKGROUND: The human leukocyte antigen (HLA)-restricted cytotoxic T-lymphocyte (CTL) immune response is one of the major factors determining the genetic diversity of human immunodeficiency virus (HIV). There are few population-based analyses of the amino acid variations associated with the host HLA type and their clinical relevance for the Asian population. Here, we identified HLA-associated polymorphisms in the...
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