Article
HLA-B∗46 associates with rapid HIV disease progression in Asian cohorts and prominent differences in NK cell phenotype.
Cell host & microbe - 10 Aug 2022
Li Shuying S, Hickey Andrew, Shangguan Shida, Ehrenberg Philip K, Geretz Aviva, Butler Lauryn, Kundu Gautam, Apps Richard, Creegan Matthew, Clifford Robert J, Pinyakorn Suteeraporn, Eller Leigh Anne, Luechai Pikunchai, Gilbert Peter B, Holtz Timothy H, Chitwarakorn Anupong, Sacdalan Carlo, Kroon Eugène, Phanuphak Nittaya, de Souza Mark, Ananworanich Jintanat, O'Connell Robert J, Robb Merlin L, Michael Nelson L, Vasan Sandhya, Thomas Rasmi
Abstract excerpt
Human leukocyte antigen (HLA) alleles have been linked to HIV disease progression and attributed to differences in cytotoxic T lymphocyte (CTL) epitope representation. These findings are largely based on treatment-naive individuals of European and African ancestry. We assessed HLA associations with HIV-1 outcomes in 1,318 individuals from Thailand and found HLA-B∗46:01 (B∗46) associated with accelerated disease...
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