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Article

Mediating effects of smoking and chronic obstructive pulmonary disease on the relation between the CHRNA5-A3 genetic locus and lung cancer risk.

Cancer - 15 Jul 2010

Wang Jian, Spitz Margaret R, Amos Christopher I, Wilkinson Anna V, Wu Xifeng, Shete Sanjay

Abstract excerpt

BACKGROUND: Recent genome-wide association studies of lung cancer have shown that the CHRNA5-A3 region on chromosome 15q24-25.1 is strongly associated with an increased risk of lung cancer and nicotine dependence, and is thought to be associated with chronic obstructive pulmonary disease as well. However, it has not been established whether the association between genetic variants and lung cancer risk is a direct...

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Source

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Identifiers

PMID: 20564069
DOI: 10.1002/cncr.25085
PMCID: PMC3073819

Genes

CHRNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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