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Targeted sequencing of chromosome 15q25 identified novel variants associated with risk of lung cancer and smoking behavior in Chinese.

Carcinogenesis - 1 May 2017

Cheng Yang, Wang Cheng, Zhu Meng, Dai Juncheng, Wang Yuzhuo, Geng Liguo, Li Zhihua, Zhang Jiahui, Ma Hongxia, Jin Guangfu, Lin Dongxin, Hu Zhibin, Shen Hongbing

Abstract excerpt

Previous genome-wide association studies (GWAS) in populations of European descent identified a lung cancer susceptibility locus at 15q25 that was biologically associated with nicotine addiction. However, the allele frequency of susceptibility variants identified in this region varied dramatically across European and Asian populations, suggesting that additional risk single nucleotide polymorphism (SNPs) in...

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PMID: 28369244
DOI: 10.1093/carcin/bgx025

Genes

CHRNA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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