Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chromosome 15q25 (CHRNA3-CHRNA5) variation impacts indirectly on lung cancer risk.

PloS one - 29 Apr 2011

Wang Yufei, Broderick Peter, Matakidou Athena, Eisen Timothy, Houlston Richard S

Abstract excerpt

Genetic variants at the 15q25 CHRNA5-CHRNA3 locus have been shown to influence lung cancer risk however there is controversy as to whether variants have a direct carcinogenic effect on lung cancer risk or impact indirectly through smoking behavior. We have performed a detailed analysis of the 15q25 risk variants rs12914385 and rs8042374 with smoking behavior and lung cancer risk in 4,343 lung cancer cases and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alleles

Share to Chromosomes, Human, Pair 15

Share to Lung Neoplasms

Share to Nerve Tissue Proteins

Share to Odds Ratio

Share to Receptors, Nicotinic

Share to Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 21559498
DOI: 10.1371/journal.pone.0019085
PMCID: PMC3084737

Genes

CHRNA3
CHRNA5
CPD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromosome 15q25 (CHRNA3-CHRNA5) variation impacts indirectly on lung cancer risk.PMID 21559498Read ↗

Chromosome 15q25 (CHRNA3-CHRNB4) Variation Indirectly Impacts Lung Cancer Risk in Chinese Males.Semantic proximity Read ↗

Genetic variants on chromosome 15q25 associated with lung cancer risk in Chinese populations.Semantic proximity Read ↗

Targeted sequencing of chromosome 15q25 identified novel variants associated with risk of lung cancer and smoking behavior in Chinese.Semantic proximity Read ↗

Genetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction.Semantic proximity Read ↗

A case-control study of a sex-specific association between a 15q25 variant and lung cancer risk.Semantic proximity Read ↗

The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer.Semantic proximity Read ↗

Nicotine dependence may link the 15q25 locus to lung cancer riskSemantic proximity Read ↗

Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.Semantic proximity Read ↗

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.Semantic proximity Read ↗

Different effects of the three polymorphisms on 15q25.1 onlung cancer risk: Evidence from published literatures.Semantic proximity Read ↗

Mediating effects of smoking and chronic obstructive pulmonary disease on the relation between the CHRNA5-A3 genetic locus and lung cancer risk.Semantic proximity Read ↗

Association between a genome-wide association study-identified locus and the risk of lung cancer in Japanese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.