Article
Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning.
Nature - 15 Jul 2010
Song Hai, Hu Jianxin, Chen Wen, Elliott Gene, Andre Philipp, Gao Bo, Yang Yingzi
Abstract excerpt
Defining the three body axes is a central event of vertebrate morphogenesis. Establishment of left-right (L-R) asymmetry in development follows the determination of dorsal-ventral and anterior-posterior (A-P) body axes, although the molecular mechanism underlying precise L-R symmetry breaking in reference to the other two axes is still poorly understood. Here, by removing both Vangl1 and Vangl2, the two mouse...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.