Article
Planar cell polarity signaling: the developing cell's compass.
Cold Spring Harbor perspectives in biology - 1 Sept 2009
Vladar Eszter K, Antic Dragana, Axelrod Jeffrey D
Abstract excerpt
Cells of many tissues acquire cellular asymmetry to execute their physiologic functions. The planar cell polarity system, first characterized in Drosophila, is important for many of these events. Studies in Drosophila suggest that an upstream system breaks cellular symmetry by converting tissue gradients to subcellular asymmetry, whereas a downstream system amplifies subcellular asymmetry and communicates...
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