Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates.

doi:10.1038/ng1644

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates.

Nature genetics - 1 Oct 2005

Ross Alison J, May-Simera Helen, Eichers Erica R, Kai Masatake, Hill Josephine, Jagger Daniel J, Leitch Carmen C, Chapple J Paul, Munro Peter M, Fisher Shannon, Tan Perciliz L, Phillips Helen M, Leroux Michel R, Henderson Deborah J, Murdoch Jennifer N, Copp Andrew J, Eliot Marie-Madeleine, Lupski James R, Kemp David T, Dollfus Hélène, Tada Masazumi, Katsanis Nicholas, Forge Andrew, Beales Philip L

Abstract excerpt

The evolutionarily conserved planar cell polarity (PCP) pathway (or noncanonical Wnt pathway) drives several important cellular processes, including epithelial cell polarization, cell migration and mitotic spindle orientation. In vertebrates, PCP genes have a vital role in polarized convergent extension movements during gastrulation and neurulation. Here we show that mice with mutations in genes involved in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bardet-Biedl Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Polarity

Share to Cilia

Share to Cochlea

Share to Eyelids

Share to Microtubule-Associated Proteins

Share to Molecular Chaperones

Share to Neural Tube Defects

Source

Open in PubMed

Identifiers

PMID: 16170314
DOI: 10.1038/ng1644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates.PMID 16170314Read ↗

Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochleaSemantic proximity Read ↗

Planar cell polarity in the inner ear.Semantic proximity Read ↗

PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates.Semantic proximity Read ↗

Mutations associated with human neural tube defects display disrupted planar cell polarity in Drosophila.Semantic proximity Read ↗

Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton.Semantic proximity Read ↗

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea.Semantic proximity Read ↗

Dual regulation of planar polarization by secreted Wnts and Vangl2 in the developing mouse cochlea.Semantic proximity Read ↗

Ciliary proteins link basal body polarization to planar cell polarity regulation.Semantic proximity Read ↗

Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo.Semantic proximity Read ↗

Identification and characterization of a novel chemically induced allele at the planar cell polarity gene Vangl2.Semantic proximity Read ↗

Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome.Semantic proximity Read ↗

The role of G protein-coupled receptors in cochlear planar cell polarity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.