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Article

Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo.

Development (Cambridge, England) - 1 Mar 2013

Mahaffey James P, Grego-Bessa Joaquim, Liem Karel F, Anderson Kathryn V

Abstract excerpt

The planar cell polarity (PCP; non-canonical Wnt) pathway is required to orient the cells within the plane of an epithelium. Here, we show that cofilin 1 (Cfl1), an actin-severing protein, and Vangl2, a core PCP protein, cooperate to control PCP in the early mouse embryo. Two aspects of planar polarity can be analyzed quantitatively at cellular resolution in the mouse embryo: convergent extension of the axial...

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Identifiers

PMID: 23406901
DOI: 10.1242/dev.085316
PMCID: PMC3585660

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