Article
Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure.
Development (Cambridge, England) - 1 Feb 2007
Ybot-Gonzalez Patricia, Savery Dawn, Gerrelli Dianne, Signore Massimo, Mitchell Claire E, Faux Clare H, Greene Nicholas D E, Copp Andrew J
Abstract excerpt
Planar-cell-polarity (PCP) signalling is necessary for initiation of neural tube closure in higher vertebrates. In mice with PCP gene mutations, a broad embryonic midline prevents the onset of neurulation through wide spacing of the neural folds. In order to evaluate the role of convergent extension in this defect, we vitally labelled the midline of loop-tail (Lp) embryos mutant for the PCP gene Vangl2. Injection...
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