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Article

Two populations of node monocilia initiate left-right asymmetry in the mouse.

Cell - 11 Jul 2003

McGrath James, Somlo Stefan, Makova Svetlana, Tian Xin, Brueckner Martina

Abstract excerpt

The vertebrate body plan has conserved handed left-right (LR) asymmetry that is manifested in the heart, lungs, and gut. Leftward flow of extracellular fluid at the node (nodal flow) is critical for normal LR axis determination in the mouse. Nodal flow is generated by motile node cell monocilia and requires the axonemal dynein, left-right dynein (lrd). In the absence of lrd, LR determination becomes random. The...

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Identifiers

PMID: 12859898
DOI: 10.1016/s0092-8674(03)00511-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Two populations of node monocilia initiate left-right asymmetry in the mouse.PMID 12859898Read ↗

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Cilia propel the embryo in the right direction.Semantic proximity Read ↗

A mutation in the zebrafish Na,K-ATPase subunit atp1a1a.1 provides genetic evidence that the sodium potassium pump contributes to left-right asymmetry downstream or in parallel to nodal flow.Semantic proximity Read ↗

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Establishment of left-right asymmetry in vertebrate development: the node in mouse embryos.Semantic proximity Read ↗

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