Assembly of productive T cell receptor delta variable region genes exhibits allelic inclusion.

doi:10.1084/jem.188.8.1465

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Article

Assembly of productive T cell receptor delta variable region genes exhibits allelic inclusion.

The Journal of experimental medicine - 19 Oct 1998

Sleckman B P, Khor B, Monroe R, Alt F W

Abstract excerpt

The generation of a productive "in-frame" T cell receptor beta (TCR beta), immunoglobulin (Ig) heavy (H) or Ig light (L) chain variable region gene can result in the cessation of rearrangement of the alternate allele, a process referred to as allelic exclusion. This process ensures that most alph...

Topics

Alleles
Animals
Gene Rearrangement, delta-Chain T-Cell Antigen Receptor
Hybridomas
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Receptors, Antigen, T-Cell, gamma-delta
T-Lymphocytes

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