Article
Vbeta cluster sequences reduce the frequency of primary Vbeta2 and Vbeta14 rearrangements.
European journal of immunology - 1 Sept 2008
Bassing Craig H, Whitlow Scott, Mostoslavsky Raul, Mostoslovasky Raul, Yang-Iott Katherine, Ranganath Sheila, Alt Frederick W
Abstract excerpt
T-cell receptor (TCR) beta variable region exons are assembled from numerous gene segments in a highly ordered and regulated manner. To elucidate mechanisms and identify cis-acting elements that control Vbeta rearrangement, we generated an endogenous TCR-beta allele with only the Vbeta2, Vbeta4, and Vbeta14 segments. We found that alphabeta T lineage cells containing this Vbeta(2-4-14) allele and a wild-type...
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