T cells recognizing an HLA-DQ alpha beta heterodimer encoded in cis by the DR4DQw4 haplotype and in trans by DR4DQw8/DRw8DQw4 heterozygous cells.

doi:10.1016/0198-8859(91)90039-c

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Article

T cells recognizing an HLA-DQ alpha beta heterodimer encoded in cis by the DR4DQw4 haplotype and in trans by DR4DQw8/DRw8DQw4 heterozygous cells.

Human immunology - 1 Mar 1991

Gjertsen H A, Lundin K E, Rønningen K S, Gaudernack G, Thorsby E

Abstract excerpt

We generated alloreactive DQ-specific CD4+ T-lymphocyte clones. One of these (TLC HH58) was only restimulated with cells having the DR4DQw4 haplotype or cells being DR4DQw8/DRw8DQw4 heterozygous. The former cells carry the DQA1*0301 and DQB1*0401 alleles in cis position while the latter cells car...

Topics

Alleles
Clone Cells
HLA-DQ Antigens
HLA-DR4 Antigen
Haplotypes
Heterozygote
Histocompatibility Testing
Humans
Lymphocyte Activation
T-Lymphocytes

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