HLA-DPbeta residue 69 plays a crucial role in allorecognition.

doi:10.1111/j.1399-0039.1998.tb03020.x

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Article

HLA-DPbeta residue 69 plays a crucial role in allorecognition.

Tissue antigens - 1 Jul 1998

Díaz G, Catálfamo M, Coiras M T, Alvarez A M, Jaraquemada D, Nombela C, Sánchez-Pérez M, Arroyo J

Abstract excerpt

To investigate the contribution to allorecognition of the individual polymorphic positions Glu 69 and Val 36 from the DPB1*02012 allele, DPB1*02012 cDNA was subjected to site-directed mutagenesis and alleles expressing Lys at 69 and Ala at 36 were generated. The lymphoblastoid cell line (LCL) 45....

Topics

Alleles
Antigen Presentation
B-Lymphocytes
Cell Line
DNA, Complementary
HLA-DP Antigens
HLA-DP beta-Chains
Humans
Immunodominant Epitopes
Lymphocyte Cooperation
Mutagenesis, Site-Directed
T-Lymphocytes

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