Article
Critical role for the Val/Gly86 HLA-DR beta dimorphism in autoantigen presentation to human T cells.
Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 1991
Ong B, Willcox N, Wordsworth P, Beeson D, Vincent A, Altmann D, Lanchbury J S, Harcourt G C, Bell J I, Newsom-Davis J
Abstract excerpt
Helper T lymphocytes recognize fragments of foreign (or self) antigens in the peptide-binding clefts of major histocompatibility complex class II molecules; their activation is a crucial step in the induction of many immune and autoimmune responses. While studying the latter, we raised a T-cell l...
Topics
- Adolescent
- Alleles
- Animals
- Antibodies, Monoclonal
- Antigen-Presenting Cells
- Autoantigens
- Cells, Cultured
- Epitopes
- Genetic Variation
- Glycine
- HLA-DR Antigens
- Haplotypes
- Humans
- Major Histocompatibility Complex