Article
Particular HLA-DQ alpha beta heterodimer associated with IDDM susceptibility in both DR4-DQw4 Japanese and DR4-DQw8/DRw8-DQw4 whites.
Diabetes - 1 Jun 1991
Rønningen K S, Gjertsen H A, Iwe T, Spurkland A, Hansen T, Thorsby E
Abstract excerpt
Insulin-dependent diabetes mellitus (IDDM) susceptibility is associated with the DR4-DQw4 haplotype in Japanese and the DR4-DQw8/-Drw8-DQw4 genotype (among others) in whites. We investigated whether these Japanese and white individuals encode the same or a similar DQ alpha beta heterodimer, which...
Topics
- Alleles
- Asian People
- B-Lymphocytes
- Cell Line
- Diabetes Mellitus, Type 1
- Disease Susceptibility
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- HLA-DR Antigens
- HLA-DR Serological Subtypes
- HLA-DR4 Antigen
- Haplotypes
- Humans
- Japan
- Lymphocyte Activation
- Macromolecular Substances
- Norway
- T-Lymphocytes