Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Particular HLA-DQ alpha beta heterodimer associated with IDDM susceptibility in both DR4-DQw4 Japanese and DR4-DQw8/DRw8-DQw4 whites.

Diabetes - 1 Jun 1991

Rønningen K S, Gjertsen H A, Iwe T, Spurkland A, Hansen T, Thorsby E

Abstract excerpt

Insulin-dependent diabetes mellitus (IDDM) susceptibility is associated with the DR4-DQw4 haplotype in Japanese and the DR4-DQw8/-Drw8-DQw4 genotype (among others) in whites. We investigated whether these Japanese and white individuals encode the same or a similar DQ alpha beta heterodimer, which may be an IDDM-susceptibility molecule in both populations. First, we carried out genomic DQA1 and DQB1 typing with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to B-Lymphocytes
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Haplotypes

Share to HLA-DR Antigens

Share to T-Lymphocytes

Source

Identifiers

PMID: 2040392
DOI: 10.2337/diab.40.6.759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Particular HLA-DQ alpha beta heterodimer associated with IDDM susceptibility in both DR4-DQw4 Japanese and DR4-DQw8/DRw8-DQw4 whites.PMID 2040392Read ↗

The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese.Semantic proximity Read ↗

HLA and non-HLA genetic factors in Japanese IDDM.Semantic proximity Read ↗

Dose effect of cis- and trans-encoded HLA-DQ alpha beta heterodimers in IDDM susceptibility.Semantic proximity Read ↗

Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM).Semantic proximity Read ↗

T cells recognizing an HLA-DQ alpha beta heterodimer encoded in cis by the DR4DQw4 haplotype and in trans by DR4DQw8/DRw8DQw4 heterozygous cells.Semantic proximity Read ↗

Sequence variation in Japanese HLA-DRw8 specificity.Semantic proximity Read ↗

Cross-ethnic group comparisons of HLA class II alleles and insulin dependent diabetes mellitus.Semantic proximity Read ↗

HLA-DP and susceptibility to insulin-dependent diabetes mellitus in Japanese.Semantic proximity Read ↗

HLA-DQA and DQB alleles contribute to susceptibility to insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Polymorphisms of HLA-DR and -DQ genes in Japanese patients with bullous pemphigoid.Semantic proximity Read ↗

Genetic analysis of HLA class II alleles and susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.Semantic proximity Read ↗

Reevaluation of human leukocyte antigen DR-DQ haplotype and genotype in type 1 diabetes in the Japanese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.