Article
Cross-reactive T cell clones from unrelated individuals reveal similarities in peptide presentation between HLA-B27 and HLA-DR2.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 1993
López D, Barber D F, Villadangos J A, López de Castro J A
Abstract excerpt
HLA-B27- responder cells were stimulated in vitro with B*2705+ lymphoblastoid cell lines and alloreactive CTL clones were obtained by limiting dilution. Of the CD3+ CD4-CD8+ HLA-B27-specific CTL clones obtained, two of them, possessing the same TCR, cross-reacted with HLA-DR2. The fine specificit...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Base Sequence
- Binding Sites, Antibody
- Binding, Competitive
- CD3 Complex
- CD8 Antigens
- Cell Line
- Clone Cells
- Cross Reactions
- Cytotoxicity Tests, Immunologic
- Epitopes
- HLA-B27 Antigen
- HLA-DR2 Antigen
- Humans
- Immunoglobulin Joining Region
- Molecular Sequence Data
- Mutation