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Article

Polymorphic HLA-DR7 beta 1 chain residues that are involved in T cell allorecognition.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1991

Rosen-Bronson S, Yu W Y, Karr R W

Abstract excerpt

The contributions to allorecognition of polymorphic amino acids in the HLA-DR7 beta 1 chain were analyzed by using mutant DR7 beta 1 chains with single amino acid substitutions at position 4, 11, 13, 25, 30, 37, 57, 60, 67, 70, 71, 74, or 78. Transfectants expressing mutant DR7 molecules were used as stimulators for six DR7-alloreactive T cell clones. The majority of the substitutions had profound effects on the...

Topics

Amino Acid Sequence
Animals
HLA-DR Antigens
Lymphocyte Activation
Mice
Molecular Sequence Data
Mutation
Protein Conformation
Structure-Activity Relationship
T-Lymphocytes
Transfection

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PMID: 2040801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2040801-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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