Article
T lymphocyte recognition of a celiac disease-associated cis- or trans-encoded HLA-DQ alpha/beta-heterodimer.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1990
Lundin K E, Sollid L M, Qvigstad E, Markussen G, Gjertsen H A, Ek J, Thorsby E
Abstract excerpt
The HLA-associated susceptibility to develop celiac disease may to a large extent be attributed to the combination of particular DQA1 and DQB1 genes, i.e., the DQA1*0501 and DBQB1*0201 alleles, located either in cis position (on the DR3DQw2 haplotype) or in trans position (DR5DQw7/DR7DQw2 heterozygous individuals). We report three alloreactive T lymphocyte clones that recognize an HLA-DQ alpha/beta heterodimer...
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