Article
Comparison of TCR-alpha beta sequences of cross-reactive anti-DR alloreactive T-cell clones: identification of possible contact residues based on charge complementarity between TCR chains and DR determinants.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Jan 2000
Champagne E, Essaket S, Huchenq A, Fabron J, Coppin H L, Sevin J, Thomsen M
Abstract excerpt
We analysed alloreactive T-cell clones selected for their differential recognition of DR variants differing in the third hypervariable region (hvr) of the DRB1 gene (amino acid positions 67-70-71). This polymorphism leads to two main hvr3 types: a basic form (Leu67-Gln70-Arg/Lys71) and an acidic form (Ile67-Asp70-Glu71) where residue 70 is probably directly accessible to the TCR on DR beta chains. The TCRs have...
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