Comparison of TCR-alpha beta sequences of cross-reactive anti-DR alloreactive T-cell clones: identification of possible contact residues based on charge complementarity between TCR chains and DR determinants.

doi:10.1111/j.1744-313x.1992.tb00044.x

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Article

Comparison of TCR-alpha beta sequences of cross-reactive anti-DR alloreactive T-cell clones: identification of possible contact residues based on charge complementarity between TCR chains and DR determinants.

European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Jan 2000

Champagne E, Essaket S, Huchenq A, Fabron J, Coppin H L, Sevin J, Thomsen M

Abstract excerpt

We analysed alloreactive T-cell clones selected for their differential recognition of DR variants differing in the third hypervariable region (hvr) of the DRB1 gene (amino acid positions 67-70-71). This polymorphism leads to two main hvr3 types: a basic form (Leu67-Gln70-Arg/Lys71) and an acidic...

Topics

Amino Acid Sequence
Base Sequence
Cross Reactions
DNA
Genetic Variation
HLA-DR Antigens
Humans
Molecular Sequence Data
Receptors, Antigen, T-Cell, alpha-beta
Sequence Homology, Nucleic Acid
T-Lymphocytes

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Identifiers

PMID: 1533151
DOI: 10.1111/j.1744-313x.1992.tb00044.x

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1533151-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.