Article
T-cell recognition of class II products that result from the combined presence of two different HLA haplotypes.
Human immunology - 1 Apr 1992
Schroeijers W E, de Koster H S, Verduyn W, Schreuder G M, Termijtelen A
Abstract excerpt
To analyze DR2 haplotypes as recognized by alloreactive T cells, lymphocytes from a DR7; DQw2 homozygous donor were cocultured with irradiated lymphocytes that were DRw15, DR7; DQw6, DQw2 heterozygous. In this report, we focus on two HLA-DQ-specific T-cell clones obtained from this priming. These two clones (c3518 and c3523) responded to the positive control (original stimulator) and five of 66 panel donors....
Topics
- Antibodies, Monoclonal
- Binding Sites, Antibody
- Binding, Competitive
- Female
- Genotype
- HLA-DQ Antigens
- HLA-DR Antigens
- Haplotypes
- Histocompatibility Testing
- Humans
- Male