Article
A 3'UTR SNP in NLRP3 gene is associated with susceptibility to HIV-1 infection.
Journal of acquired immune deficiency syndromes (1999) - 1 Jul 2010
Pontillo Alessandra, Brandão Lucas A, Guimarães Rafael L, Segat Ludovica, Athanasakis Emmanouil, Crovella Sergio
Abstract excerpt
OBJECTIVES: Innate immunity genes polymorphisms are known to be involved in the multifactorial susceptibility to HIV-1 infection. Recently it has been hypothesized that inflammasomes could play an important role in the host response to viruses. The aim of our study is to verify if single-nucleotide polymorphisms (SNPs) in genes encoding for NALPs-innate immune receptors that form molecular complexes leading to...
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