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Article

Association between subclinical atherosclerosis and NLRP3 rs10157379 and rs10754558 genetic variants, inflammatory, and metabolic biomarkers in HIV-1 infection.

Human immunology - 1 Sept 2026

Bellinati Philipe Quagliato, Lozovoy Marcell Alysson Batisti, Ahrens Tainah Mendes, Gaspareto Junior Paulo Fernando, Dos Santos Eduarda, de Araujo Daniel Nascimento Ferreira, Alvarenga Thiago Matias, Sakamoto Luana Machado, Dos Santos Daniel Felipe Piva, Fajardo Julia Zampa, Trigo Guilherme Lerner, de Sousa Cassela Pedro Luís Cândido, Martins Caio Hideki Cruz, Alfieri Daniela Frizon, Simão Andrea Name Colado, Reiche Edna Maria Vissoci

Abstract excerpt

The NLRP3 inflammasome, along with inflammatory and metabolic biomarkers, has been implicated in atherosclerosis. This study aimed to investigate the association between subclinical atherosclerosis and NLRP3 rs10157379 T > C and rs10754558 C > G variants, inflammatory and metabolic biomarkers, and HIV-1 viral load in individuals living with HIV-1 infection. Seventy-eight HIV-1-infected individuals receiving...

Read the complete abstract on PubMed

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Topics

Humans
NLR Family, Pyrin Domain-Containing 3 Protein
Female
HIV Infections
Male
Middle Aged
Biomarkers
Atherosclerosis
HIV-1
Carotid Intima-Media Thickness
Viral Load
Genotype
Polymorphism, Single Nucleotide
Genetic Predisposition to Disease
Adult
Inflammation

Source

Identifiers

PMID: 42468072
DOI: 10.1016/j.humimm.2026.111804

Genes

NLRP3
CD4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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