Article
Inflammasome genetic variants are associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes.
Frontiers in cellular and infection microbiology - 1 Jan 2022
de Sá Nathalia Beatriz Ramos, de Souza Nara Cristina Silva, Neira-Goulart Milena, Ribeiro-Alves Marcelo, Da Silva Tatiana Pereira, Pilotto Jose Henrique, Rolla Valeria Cavalcanti, Giacoia-Gripp Carmem B W, de Oliveira Pinto Luzia Maria, Scott-Algara Daniel, Morgado Mariza Gonçalves, Teixeira Sylvia Lopes Maia
Abstract excerpt
Background: Tuberculosis (TB) and AIDS are the leading causes of infectious diseases death worldwide. Here, we investigated the relationship between from single nucleotide polymorphisms (SNPs) of the NLRP3, CARD8, AIM2, CASP-1, IFI16, and IL-1β inflammasome genes, as well as the profiles of secreted proinflammatory cytokines (e.g., IL-1β, IL-18, IL-33, and IL-6) with the TB clinical profiles, TB-HIV coinfection,...
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