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Article

Antagonistic role of IL-1ß and NLRP3/IL-18 genetics in chronic HIV-1 infection.

Clinical immunology (Orlando, Fla.) - 1 Dec 2019

Reis Edione C, Leal Vinicius N C, da Silva Lais T, Dos Reis Marilia M L, Argañaraz Enrique R, Oshiro Telma M, Pontillo Alessandra

Abstract excerpt

Host genetics affects both susceptibility and progression of HIV-1 infection. NLRP3 inflammasome provides a first-line defense in viral infections, and, accordingly, gain-of-function variants in NLRP3 have been associated with protection against HIV-1. Despite antiretroviral treatment (ART), HIV-infected patients continue to present systemic inflammation with a heterogeneous prognosis. As NLRP3 inflammasome is...

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Identifiers

PMID: 31669192
DOI: 10.1016/j.clim.2019.108266

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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