Article
Chemokines SNPs in HIV-1+ Patients and Healthy Controls from Northeast Brazil: Association with Protection against HIV-1 Infection.
Current HIV research - 1 Jan 2016
Celerino da Silva Ronaldo, Victor Campos Coelho Antonio, Cláudio Arraes Luiz, André Cavalcanti Brandão Lucas, Lima Guimarães Rafael, Crovella Sergio
Abstract excerpt
BACKGROUND: HIV-1 virus is known to infect the host mainly through CD4+ T-lymphocyte cells, by interactions among the viral envelope proteins, CD4 receptor and HIV-1 coreceptors, such as chemokines receptors. Variations in the genes encoding HIV-1 coreceptors and their natural ligands have been shown to modify HIV-1 infection susceptibility and disease progression. METHODS AND RESULTS: We analysed the...
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