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Article

Genetic variation and circulating levels of IGF-I and IGFBP-3 in relation to risk of proliferative benign breast disease.

International journal of cancer - 1 Jan 2010

Su Xuefen, Colditz Graham A, Willett Walter C, Collins Laura C, Schnitt Stuart J, Connolly James L, Pollak Michael N, Rosner Bernard, Tamimi Rulla M

Abstract excerpt

Insulin-like growth factor-I (IGF-I) and its major binding protein IGFBP-3 have been implicated in breast carcinogenesis. We examined the associations between genetic variants and circulating levels of IGF-I and IGFBP-3 with proliferative benign breast disease (BBD), a marker of increased breast cancer risk, in the Nurses' Health Study II (NHSII). Participants were 359 pathology-confirmed proliferative BBD cases...

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Identifiers

PMID: 19551864
DOI: 10.1002/ijc.24674
PMCID: PMC2783930

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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