Article
Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium.
Human molecular genetics - 1 Oct 2010
Canzian Federico, Cox David G, Setiawan V Wendy, Stram Daniel O, Ziegler Regina G, Dossus Laure, Beckmann Lars, Blanché Hélène, Barricarte Aurelio, Berg Christine D, Bingham Sheila, Buring Julie, Buys Saundra S, Calle Eugenia E, Chanock Stephen J, Clavel-Chapelon Françoise, DeLancey John Oliver L, Diver W Ryan, Dorronsoro Miren, Haiman Christopher A, Hallmans Göran, Hankinson Susan E, Hunter David J, Hüsing Anika, Isaacs Claudine, Khaw Kay-Tee, Kolonel Laurence N, Kraft Peter, Le Marchand Loïc, Lund Eiliv, Overvad Kim, Panico Salvatore, Peeters Petra H M, Pollak Michael, Thun Michael J, Tjønneland Anne, Trichopoulos Dimitrios, Tumino Rosario, Yeager Meredith, Hoover Robert N, Riboli Elio, Thomas Gilles, Henderson Brian E, Kaaks Rudolf, Feigelson Heather Spencer
Abstract excerpt
There is extensive evidence that increases in blood and tissue concentrations of steroid hormones and of insulin-like growth factor I (IGF-I) are associated with breast cancer risk. However, studies of common variation in genes involved in steroid hormone and IGF-I metabolism have yet to provide convincing evidence that such variants predict breast cancer risk. The Breast and Prostate Cancer Cohort Consortium...
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