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Article

CCR1- and CCR5-mediated inactivation of leukocytes by a nonglycosaminoglycan (non-GAG)-binding variant of n-nonanoyl-CCL14 (NNY-CCL14).

Journal of leukocyte biology - 1 Aug 2010

Gupta Shipra, Rieder Sebastian, Richter Rudolf, Schulz-Maronde Sandra, Manns Johanna, Escher Sylvia E, Heitland Aleksandra, Mack Matthias, Forssmann Wolf-Georg, Elsner Jörn, Forssmann Ulf

Abstract excerpt

Intervention on chemokine receptors to prevent directional leukocyte migration is a potential therapeutic strategy. NNY-CCL14 is a CD26-resistant lead molecule, which exerts its effects on multiple chemokine receptors (CCR1, CCR2, CCR3, and CCR5). The inhibitory effects of NNY-CCL14 in murine models of allergic airway inflammation have been assigned to its interaction with CCR1 and CCR5. In this study, a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20483925
DOI: 10.1189/jlb.0509366

Genes

CCL14
CCR1
CCR5
CCR2
CCR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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