Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The amino terminus and the third extracellular loop of CX3CR1 contain determinants critical for distinct receptor functions.

Molecular pharmacology - 1 Mar 2006

Chen Yiming, Green Simone R, Almazan Felicidad, Quehenberger Oswald

Abstract excerpt

The G protein-coupled receptor CX3CR1 is a specific receptor for the CX3C chemokine fractalkine (CX3CL1 according to the new chemokine nomenclature). The aim of this study was to identify receptor elements that contribute independently to agonist binding and receptor activation. Targeted mutation of selected acidic amino acid residues demonstrated that the binding activity of CX3CR1 was critically dependent on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asparagine
Share to Chemotaxis
Share to CX3C Chemokine Receptor 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamine

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to Receptors, Chemokine

Share to Tyrosine

Source

Identifiers

PMID: 16317113
DOI: 10.1124/mol.105.015909

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The amino terminus and the third extracellular loop of CX3CR1 contain determinants critical for distinct receptor functions.PMID 16317113Read ↗

Molecular determinants of receptor binding and signaling by the CX3C chemokine fractalkine.Semantic proximity Read ↗

Modulation of chemoattractant receptor function by C-terminus interactionsSemantic proximity Read ↗

Alanine scanning mutagenesis of the chemokine receptor CCR3 reveals distinct extracellular residues involved in recognition of the eotaxin family of chemokines.Semantic proximity Read ↗

Identification of receptor binding and activation determinants in the N-terminal and N-loop regions of the CC chemokine eotaxin.Semantic proximity Read ↗

Third extracellular loop (EC3)-N terminus interaction is important for seven-transmembrane domain receptor function: implications for an activation microswitch region.Semantic proximity Read ↗

Differential activity and selectivity of N-terminal modified CXCL12 chemokines at the CXCR4 and ACKR3 receptors.Semantic proximity Read ↗

The chemokine CX3CL1 (fractalkine) and its receptor CX3CR1: occurrence and potential role in osteoarthritis.Semantic proximity Read ↗

Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1.Semantic proximity Read ↗

Chemokine receptor mutant CX3CR1-M280 has impaired adhesive function and correlates with protection from cardiovascular disease in humans.Semantic proximity Read ↗

CC and CX3C Chemokines Differentially Interact with the N Terminus of the Human Cytomegalovirus-encoded US28 ReceptorSemantic proximity Read ↗

Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.Semantic proximity Read ↗

An overall picture of chemokine receptors: basic research and drug development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.