Article

Investigating the orchestration of the inflammatory response : a role for chemokine receptors CCR1, CCR2, CCR3 and CCR5

2019-01-01

Abstract excerpt

Despite over 20 years of pharmaceutical targeted research, no antagonist of inflammatory chemokine receptors (iCCR) has been licensed for use in treating inflammatory diseases. Marked promiscuity of ligand binding, simultaneous expression of multiple chemokine receptors in individual leukocytes and the inability to generate compound receptor knock out mice make it almost impossible to discern the function of a spe...

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Identifiers and source

Literature Corpus work: 8b208317-a479-5e70-906c-4bb32943397b
DOI: 10.5525/gla.thesis.76731

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