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Article

Rationally evolving MCP-1/CCL2 into a decoy protein with potent anti-inflammatory activity in vivo.

The Journal of biological chemistry - 19 Mar 2010

Piccinini Anna Maria, Knebl Kerstin, Rek Angelika, Wildner Gerhild, Diedrichs-Möhring Maria, Kungl Andreas J

Abstract excerpt

Leukocyte recruitment from the blood into injured tissues during inflammatory diseases is the result of sequential events involving chemokines binding to their GPC receptors as well as to their glycosaminoglycan (GAG) co-receptors. The induction and the crucial role of MCP-1/CCL2 in the course of diseases that feature monocyte-rich infiltrates have been validated in many animal models, and several MCP-1/CCL2 as...

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Share to Anti-Inflammatory Agents
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20097750
DOI: 10.1074/jbc.M109.043299
PMCID: PMC2838300

Genes

CCL2
CCR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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