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Article

Identification of receptor binding and activation determinants in the N-terminal and N-loop regions of the CC chemokine eotaxin.

The Journal of biological chemistry - 27 Apr 2001

Mayer M R, Stone M J

Abstract excerpt

Eotaxin is a CC chemokine that specifically activates the receptor CCR3 causing accumulation of eosinophils in allergic diseases and parasitic infections. Twelve amino acid residues in the N-terminal (residues 1-8) and N-loop (residues 11-20) regions of eotaxin have been individually mutated to a...

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Source

Identifiers

PMID: 11297526
DOI: 10.1074/jbc.M011202200

Genes

CCR3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11297526-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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