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Article

Differential activity and selectivity of N-terminal modified CXCL12 chemokines at the CXCR4 and ACKR3 receptors.

Journal of leukocyte biology - 1 Jun 2020

Jaracz-Ros Agnieszka, Bernadat Guillaume, Cutolo Pasquale, Gallego Carmen, Gustavsson Martin, Cecon Erika, Baleux Françoise, Kufareva Irina, Handel Tracy M, Bachelerie Françoise, Levoye Angélique

Abstract excerpt

Chemokines play critical roles in numerous physiologic and pathologic processes through their action on seven-transmembrane (TM) receptors. The N-terminal domain of chemokines, which is a key determinant of signaling via its binding within a pocket formed by receptors' TM helices, can be the target of proteolytic processing. An illustrative case of this regulatory mechanism is the natural processing of CXCL12...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32374043
DOI: 10.1002/JLB.2MA0320-383RR
PMCID: PMC7540625

Genes

CXCL12
ACKR3
CXCR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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