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Article

Identification of a protein-protein interaction between KCNE1 and the activation gate machinery of KCNQ1.

The Journal of general physiology - 1 Jun 2010

Lvov Anatoli, Gage Steven D, Berrios Virla M, Kobertz William R

Abstract excerpt

KCNQ1 channels assemble with KCNE1 transmembrane (TM) peptides to form voltage-gated K(+) channel complexes with slow activation gate opening. The cytoplasmic C-terminal domain that abuts the KCNE1 TM segment has been implicated in regulating KCNQ1 gating, yet its interaction with KCNQ1 has not been described. Here, we identified a protein-protein interaction between the KCNE1 C-terminal domain and the KCNQ1 S6...

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Source

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Identifiers

PMID: 20479109
DOI: 10.1085/jgp.200910386
PMCID: PMC2888057

Genes

KCNQ1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Identification of a protein-protein interaction between KCNE1 and the activation gate machinery of KCNQ1.PMID 20479109Read ↗

Photo-Cross-Linking of IKs Demonstrates State-Dependent Interactions between KCNE1 and KCNQ1.Semantic proximity Read ↗

The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure.Semantic proximity Read ↗

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Role of the S6 C-terminus in KCNQ1 channel gating.Semantic proximity Read ↗

Functional Interactions between KCNE1 C-Terminus and the KCNQ1 ChannelSemantic proximity Read ↗

Secondary structure transitions and dual PIP2 binding define cardiac KCNQ1-KCNE1 channel gatingSemantic proximity Read ↗

Probing the interaction between KCNE2 and KCNQ1 in their transmembrane regions.Semantic proximity Read ↗

Characterization of KCNQ1 atrial fibrillation mutations reveals distinct dependence on KCNE1.Semantic proximity Read ↗

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Characterization of an LQT5-related mutation in KCNE1, Y81C: implications for a role of KCNE1 cytoplasmic domain in IKs channel function.Semantic proximity Read ↗

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