Article
The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure.
The Journal of biological chemistry - 7 Jan 2011
Labro Alain J, Boulet Inge R, Choveau Frank S, Mayeur Evy, Bruyns Tine, Loussouarn Gildas, Raes Adam L, Snyders Dirk J
Abstract excerpt
In vivo, KCNQ1 α-subunits associate with the β-subunit KCNE1 to generate the slowly activating cardiac potassium current (I(Ks)). Structurally, they share their topology with other Kv channels and consist out of six transmembrane helices (S1-S6) with the S1-S4 segments forming the voltage-sensing domain (VSD). The opening or closure of the intracellular channel gate, which localizes at the bottom of the S6...
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