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Article

Role of the S6 C-terminus in KCNQ1 channel gating.

The Journal of physiology - 1 Dec 2007

Boulet Inge R, Labro Alain J, Raes Adam L, Snyders Dirk J

Abstract excerpt

Co-assembly of KCNQ1 alpha-subunits with KCNE1 beta-subunits results in the channel complex underlying the cardiac IKs current in vivo. Like other voltage-gated K+ channels, KCNQ1 has a tetrameric configuration. The S6 segment of each subunit lines the ion channel pore with the lower part forming the activation gate. To determine residues involved in protein-protein interactions in the C-terminal part of S6...

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Source

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Identifiers

PMID: 17932138
DOI: 10.1113/jphysiol.2007.145813
PMCID: PMC2375480

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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