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Article

Probing the interaction between KCNE2 and KCNQ1 in their transmembrane regions.

The Journal of membrane biology - 1 Apr 2007

Liu Xian-Sheng, Zhang Mei, Jiang Min, Wu Dong-Mei, Tseng Gea-Ny

Abstract excerpt

KCNE1-KCNE5 are single membrane-spanning proteins that associate with voltage-gated potassium channels to diversify their function. Other than the KCNQ1/KCNE1 complex, little is known about how KCNE proteins work. We focus on KCNE2, which associates with KCNQ1 to form K channels critical for gastric acid secretion in parietal cells. We use cysteine (Cys)-scanning mutagenesis to probe the functional role of...

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Source

Identifiers

PMID: 17676362
DOI: 10.1007/s00232-007-9047-7

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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