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Article

Photo-Cross-Linking of IKs Demonstrates State-Dependent Interactions between KCNE1 and KCNQ1.

Biophysical journal - 25 Jul 2017

Westhoff Maartje, Murray Christopher I, Eldstrom Jodene, Fedida David

Abstract excerpt

The slow delayed rectifier potassium current (IKs) is a key repolarizing current during the cardiac action potential. It consists of four KCNQ1 α-subunits and up to four KCNE1 β-subunits, which are thought to reside within external clefts of the channel. The interaction of KCNE1 with KCNQ1 dramatically delays opening of the channel but the mechanisms by which this occur are not yet fully understood. Here, we have...

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Source

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Identifiers

PMID: 28746852
DOI: 10.1016/j.bpj.2017.06.005
PMCID: PMC5529200

Genes

KCNQ1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Photo-Cross-Linking of IKs Demonstrates State-Dependent Interactions between KCNE1 and KCNQ1.PMID 28746852Read ↗

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Gating and Regulation of KCNQ1 and KCNQ1 + KCNE1 Channel ComplexesSemantic proximity Read ↗

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