Article
Analysis of the Micro-RNA-133 and PITX3 genes in Parkinson's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2010
de Mena Lorena, Coto Eliecer, Cardo Lucía F, Díaz Marta, Blázquez Marta, Ribacoba René, Salvador Carlos, Pastor Pau, Samaranch Lluis, Moris Germán, Menéndez Manuel, Corao Ana I, Alvarez Victoria
Abstract excerpt
MicroRNAs are small RNA sequences that negatively regulate gene expression by binding to the 3' untranslated regions of mRNAs. MiR-133b has been implicated in Parkinson's disease (PD) by a mechanism that involves the regulation of the transcription factor PITX3. The variation in these genes could contribute to the risk of developing PD. We searched for DNA variants in miR-133 and PITX3 genes in PD patients and...
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