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Article

Association of transcription factor polymorphisms PITX3 and EN1 with Parkinson's disease.

Neurobiology of aging - 1 Feb 2011

Haubenberger Dietrich, Reinthaler Eva, Mueller Jakob C, Pirker Walter, Katzenschlager Regina, Froehlich Roman, Bruecke Thomas, Daniel Gerhard, Auff Eduard, Zimprich Alexander

Abstract excerpt

The transcription factors PITX3 and Engrailed 1 (EN1), among others, have been shown to play a crucial role in the maturation and survival of midbrain dopaminergic neurons. The degeneration of those neurons is the pathological hallmark in Parkinson's disease (PD). In a hypothesis-driven candidate gene approach, it has been recently shown that polymorphisms in the genes coding for PITX3 and EN1 are associated with...

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Source

Identifiers

PMID: 19345444
DOI: 10.1016/j.neurobiolaging.2009.02.015

Genes

PITX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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