Article
PITX3 polymorphism is associated with early onset Parkinson's disease.
Neurobiology of aging - 1 Jan 2010
Bergman Olle, Håkansson Anna, Westberg Lars, Nordenström Kajsa, Carmine Belin Andrea, Sydow Olof, Olson Lars, Holmberg Björn, Eriksson Elias, Nissbrandt Hans
Abstract excerpt
PITX3 is a transcription factor of importance for the differentiation and survival of midbrain dopaminergic neurons, the gene of which is disrupted in a putative mouse model for Parkinson's disease (PD). The A-allele of a HapMap tagging SNP (rs4919621) that was genotyped in a population of 361 PD patients, 69 of which had early onset, and in 333 controls, was significantly more common in PD patients with an early...
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