Article
Resolving Toxic DNA repair intermediates in every E. coli replication cycle: critical roles for RecG, Uup and RadD.
Nucleic acids research - 4 Sept 2020
Romero Zachary J, Chen Stefanie H, Armstrong Thomas, Wood Elizabeth A, van Oijen Antoine, Robinson Andrew, Cox Michael M
Abstract excerpt
DNA lesions or other barriers frequently compromise replisome progress. The SF2 helicase RecG is a key enzyme in the processing of postreplication gaps or regressed forks in Escherichia coli. A deletion of the recG gene renders cells highly sensitive to a range of DNA damaging agents. Here, we demonstrate that RecG function is at least partially complemented by another SF2 helicase, RadD. A ΔrecGΔradD double...
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