Article
RecQ promotes toxic recombination in cells lacking recombination intermediate-removal proteins.
Molecular cell - 27 Apr 2007
Magner Daniel B, Blankschien Matthew D, Lee Jennifer A, Pennington Jeanine M, Lupski James R, Rosenberg Susan M
Abstract excerpt
The RecQ-helicase family is widespread, is highly conserved, and includes human orthologs that suppress genomic instability and cancer. In vivo, some RecQ homologs promote reduction of steady-state levels of bimolecular recombination intermediates (BRIs), which block chromosome segregation if not resolved. We find that, in vivo, E. coli RecQ can promote the opposite: the net accumulation of BRIs. We report that...
Topics
- Bacterial Proteins
- DNA Helicases
- DNA Repair
- DNA Replication Timing
- DNA-Binding Proteins
- Endodeoxyribonucleases
- Escherichia coli
- Escherichia coli Proteins
- Exodeoxyribonucleases
- In Situ Hybridization, Fluorescence