Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disintegration of nascent replication bubbles during thymine starvation triggers RecA- and RecBCD-dependent replication origin destruction.

The Journal of biological chemistry - 6 Jul 2012

Kuong Kawai J, Kuzminov Andrei

Abstract excerpt

Thymineless death strikes cells unable to synthesize DNA precursor dTTP, with the nature of chromosomal damage still unclear. Thymine starvation stalls replication forks, whereas accumulating evidence indicates the replication origin is also affected. Using a novel DNA labeling technique, here we show that replication slowly continues in thymine-starved cells, but the newly synthesized DNA becomes fragmented and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Damage
Share to DNA Repair
Share to DNA Replication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli Proteins

Share to Exodeoxyribonuclease V

Share to Rec A Recombinases

Share to Replication Origin

Share to Thymine

Source

Open in PubMed Open full text

Identifiers

PMID: 22621921
DOI: 10.1074/jbc.M112.359687
PMCID: PMC3390671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disintegration of nascent replication bubbles during thymine starvation triggers RecA- and RecBCD-dependent replication origin destruction.PMID 22621921Read ↗

Stalled replication fork repair and misrepair during thymineless death in Escherichia coli.Semantic proximity Read ↗

Thymine-starvation-induced chromosomal fragmentation is not required for thymineless death in Escherichia coli.Semantic proximity Read ↗

Patterns of chromosomal fragmentation due to uracil-DNA incorporation reveal a novel mechanism of replication-dependent double-stranded breaks.Semantic proximity Read ↗

Thymine metabolism and thymineless death in prokaryotes and eukaryotes.Semantic proximity Read ↗

Chromosome demise in the wake of ligase-deficient replication.Semantic proximity Read ↗

RdgB acts to avoid chromosome fragmentation in Escherichia coli.Semantic proximity Read ↗

Genomic mapping of single-stranded DNA in hydroxyurea-challenged yeasts identifies origins of replication.Semantic proximity Read ↗

Multiple origins of replication contribute to a discontinuous pattern of DNA synthesis across the T4 genome during infection.Semantic proximity Read ↗

Thymine starvation-induced structural changes in Escherichia coli DNA. Detection by pulsed field gel electrophoresis and evidence for involvement of homologous recombination.Semantic proximity Read ↗

Broken replication forks trigger heritable DNA breaks in the terminus of a circular chromosome.Semantic proximity Read ↗

Monitoring S phase progression globally and locally using BrdU incorporation in TK(+) yeast strains.Semantic proximity Read ↗

Defects in the central metabolism prevent thymineless death in Escherichia coli, while still allowing significant protein synthesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.