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Article

Thymine-starvation-induced chromosomal fragmentation is not required for thymineless death in Escherichia coli.

Molecular microbiology - 1 May 2022

Khan Sharik R, Kuzminov Andrei

Abstract excerpt

Thymine or thymidine starvation induces robust chromosomal fragmentation in Escherichia coli thyA deoCABD mutants and is proposed to be the cause of thymineless death (TLD). However, fragmentation kinetics challenges the idea that fragmentation causes TLD, by peaking before the onset of TLD and disappearing by the time TLD accelerates. Quantity and kinetics of fragmentation also stay unchanged in...

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PMID: 35324030
DOI: 10.1111/mmi.14897
PMCID: PMC11574965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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