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Article

Defects in the central metabolism prevent thymineless death in Escherichia coli, while still allowing significant protein synthesis.

Genetics - 6 Nov 2024

Khan Sharik R, Kuzminov Andrei

Abstract excerpt

Starvation of Escherichia coli thyA auxotrophs for the required thymine or thymidine leads to the cessation of DNA synthesis and, unexpectedly, to thymineless death (TLD). Previously, TLD-alleviating defects were identified by the candidate gene approach, for their contribution to replication initiation, fork repair, or SOS induction. However, no TLD-blocking mutations were ever found, suggesting a multifactorial...

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Identifiers

PMID: 39212478
DOI: 10.1093/genetics/iyae142
PMCID: PMC11538421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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